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Anagrelide is used to treat a certain blood disorder (thrombocythemia), which is caused by your bone marrow making too many platelets. Platelets are a blood cell that the body uses to form blood clots. Too many platelets can cause problems with your circulation, including unwanted blood clots and bleeding problems. Agrylin reduces the number of platelets in the bloodstream by blocking their production.

This medicine may come with a Patient Information Leaflet. Read it carefully if available. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. Take Agrylin by mouth with or without food, usually 2 or 4 times a day or as directed by your doctor. Children or people with liver problems may start out by taking only 1 dose each day. Your doctor will adjust your dose, usually once a week, to find the best dose for you that keeps your blood counts closer to normal. The Dosage of Agrylin is based on your medical condition and response to therapy. You should not take more than 2.5 milligrams in a single dose or more than a total of 10 milligrams in a day. Use Agrylin regularly in order to get the most benefit from it. To help you remember, take it at the same times each day. Keep taking Agrylin even if you feel well. People with high platelets may not feel sick. Do not stop taking Agrylin without consulting your doctor. Stopping anagrelide will cause your platelets to go back up. Your doctor will check your blood counts regularly to monitor your progress and adjust your dose.

Before taking anagrelide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Agrylin may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Agrylin, tell your doctor or pharmacist your medical history,heart problems (e.g., heart attack, irregular heartbeat), lung problems, kidney problems, liver problems. Agrylin may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Anagrelide may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using anagrelide,certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using anagrelide safely. Before having surgery, tell your doctor or dentist that you are using Agrylin. Older adults may be more sensitive to the side effects of Agrylin, especially QT prolongation (see above). During pregnancy, Agrylin should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if Agrylin passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using Agrylin and for 1 week after stopping Agrylin. Consult your doctor before breast-feeding.

If you miss a dose of Agrylin, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.other drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as warfarin/enoxaparin), sucralfate. Only take aspirin if your doctor approves of it. Aspirin can increase the risk of bleeding when used with anagrelide, especially if you already have a high risk for bleeding. However, if your doctor has directed you to take low-dose aspirin to prevent blood clots, or for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Discuss the risks and benefits with your doctor or pharmacist. Many drugs besides anagrelide may affect the heart rhythm (QT prolongation), including amiodarone, chloroquine, clarithromycin, disopyramide, haloperidol, methadone, moxifloxacin, pimozide, procainamide, among others.

What are Agrylin side effects?

Side effects are physical, mental or emotional symptoms which occur in addition to or outside of the desired effect of a therapeutic treatment such as an over-the-counter or prescribed drug or medication. Side effects from Agrylin may occur at the beginning or at the end of treatment and may also depend on the length of time an individual remains on the treatment. Side effects, also known as adverse effects, are generally more likely to occur when starting treatment. Individuals may also experience side effects from Agrylin as a result of an interaction with other medications.

Side Effects of Agrylin

The side effects of Agrylin may vary in number and intensity for many different reasons. Factors such as age, weight, gender and ethnicity may influence the side effects of Agrylin. Also, an individual’s state of general physical health and seriousness of the disease or illness as well as an increase or decrease in dosage may lead to side effects. Further, side effects from Agrylin may also occur as a result of an interaction with certain herbal supplements, foods or drinks.

Prescription drug side effects can be serious and may cause patients to stop the treatment. However, when side effects from the use of a prescription drug, such as Agrylin, do occur a patient should consult their physician. A physician may prescribe an additional treatment in order to control the symptoms or an adjustment in the dosage may be made. In addition, changes to diet, exercise or other lifestyle activities may help to lessen the side effects of Agrylin.

By understanding side effects and the factors which may influence the occurrence of side effects patients are empowered to take an active role in their care. Patients who have specific questions about the side effects of Agrylin, or any other medication, should contact their physician. General information about Agrylin and the side effects associated with Agrylin are described in the following:

Common Agrylin Side Effects
  • pulmonary infiltrates
Less Severe
  • dyspepsia
  • pruritus of skin
  • back pain
  • dizziness
  • fever
  • general weakness
  • malaise
  • paresthesia
  • edema
  • anorexia
  • headache disorder
  • tachycardia
  • palpitations
  • dyspnea
  • cough
  • chest pain
  • nausea
  • vomiting
  • flatulence
  • diarrhea
  • acute abdominal pain
  • pain
  • peripheral edema
Less Frequent Agrylin Side Effects
  • thrombocytopenic disorder
  • acute myocardial infarction
  • pericarditis
  • cardiomyopathy
  • complete atrioventricular block
  • atrial fibrillation
  • chronic heart failure
  • cardiomegaly
  • cerebrovascular accident
  • pneumonia
  • bronchitis
  • asthma
  • cardiac arrhythmia
  • hemorrhage
  • angina
  • gastrointestinal hemorrhage
Less Severe
  • acute confusion
  • depression
  • diplopia
  • epistaxis
  • tinnitus
  • vasodilation of blood vessels
  • pharyngitis
  • rhinitis
  • aphthous stomatitis
  • constipation
  • hematuria
  • skin photosensitivity
  • arthralgia
  • myalgia
  • cramps in legs
  • drowsy
  • insomnia
  • chills
  • skin rash
  • dysuria
  • nervousness
  • flu-like symptoms
  • hypertension
  • orthostatic hypotension
  • syncope
  • gastritis
  • black tarry stools
  • eructation
  • anemia
  • ecchymosis
  • lymphadenopathy
  • dehydration
  • visual changes
  • memory impairment
  • amblyopia
  • hypotension
Rare or Very Rare Agrylin Side Effects
  • pulmonary hypertension
  • interstitial nephritis
  • pulmonary fibrosis
  • interstitial lung disease
  • gastrointestinal ulcer
  • pancreatitis
  • seizure disorder
  • abnormal hepatic function tests
  • renal failure
  • prolonged QT interval
  • torsades de pointes
  • pleural effusions
  • ventricular tachycardia
  • eosinophilic pneumonia
  • hepatitis
  • leukocytosis
  • supraventricular tachycardia
Less Severe
  • alopecia
  • hypesthesia

Store at room temperature away from light and moisture. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Agrylin when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Agrylin Drug Information

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Additional information


0.5mg, 1mg


100, 200, 300